HPV human papillomavirus is the cause of genital warts, which are painless flesh-colored warts that occur in clusters on the penis and in the genital region the area covered by boxer shorts. It happens when the lymph channels in your penis are temporarily blocked. Medically Reviewed by J.

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A painful blister or sore on your penis could be caused by herpes , which is an STI caused by the herpes simplex virus. Back to Men's health. Syphilis causes a chancre or ulcer at the site of infection that disappears on its own in weeks.

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Lymphocele This is a hard swelling that suddenly appears on the shaft of the penis after sex or masturbation. Check a doctor's response to similar questions.

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They can affect the penis and general groin area, in which case it's considered an STI. Worried about a spot, lump or growth on your penis?

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Respond to patient questions and discuss challenging presentations with other members. Peyronie's disease is an uncommon condition that causes a thickened area or hard lump plaque in the shaft of the penis. Cancer of the penis Penile cancer is a rare type of cancer that can cause a sore or lump on the penis, most commonly on the head of the penis.